After the highly publicized debate between President Barack Obama and Governor Mitt Romney, the vice-presidential candidates are up next.

Vice President Joe Biden will square off against Republican candidate Paul Ryan, in what will likely be an animated debate.

The highly experienced Biden will do his best to challenge the up-and-coming Ryan, with economic policy and Medicare likely to be central topics.

While Ryan has never debated before on the national, televised level, Biden has three decades of political experience, has run for president and is no stranger to the challenges.

Ryan will likely have to back up some of the claims Romney made during the first presidential debate, while Biden will look to poke holes in what critics generally applauded as a strong debate for the Republican candidate.

Both sides have been preparing for the debate, with both Biden and Ryan taking part in mock debates to prepare for the prime time.

The debate is scheduled for Thursday, October 11 at 9 p.m.